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| Denzel Washington | ... | Malcolm X |
| Angela Bassett | ... | Betty Shabazz |
| Albert Hall | ...
| Baines |
| Al Freeman Jr. | ... | Elijah Muhammad |
| Delroy Lindo | ... | West Indian Archie |
| Spike Lee | ...Where can i watch once on this island Once on this island disney plusWho wrote once on this islandOnce on this island cast 2023Once on this island plot | Shorty |
| Theresa Randle | ... | Laura |
| Kate Vernon | ... | Sophia |
| Lonette McKee | ... | Louise Little |
| Tommy Hollis | ...
| Earl Little |
| James McDaniel | ... | Brother Earl |
| Ernest Thomas | ... | Sidney |
| Jean-Claude La Marre | ...Once on this island cast | Benjamin 2X (as Jean LaMarre) |
| O.L. Duke | ... | Pete |
| Larry McCoy | ... | Sammy |
| Maurice Sneed | ... | Cadillac |
| Debi Mazar | ...
| Peg |
| Phyllis Yvonne Stickney | ...Once on this island plot | Honey |
| Scot Anthony Robinson | ... | Daniel |
| Sonny Jim Gaines | ... | Cholly (as James E. Gaines) |
| Joe Seneca | ...
| Toomer |
| LaTanya Richardson Jackson | ... | Lorraine (as Latanya Richardson) |
| Wendell Pierce | ... | Ben Thomas |
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